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Mutant IP(3) receptors attenuate store-operated Ca(2+) entry by destabilizing STIM–Orai interactions in Drosophila neurons
Store-operated Ca(2+) entry (SOCE) occurs when loss of Ca(2+) from the endoplasmic reticulum (ER) stimulates the Ca(2+) sensor, STIM, to cluster and activate the plasma membrane Ca(2+) channel Orai (encoded by Olf186-F in flies). Inositol 1,4,5-trisphosphate receptors (IP(3)Rs, which are encoded by...
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| Publicado no: | J Cell Sci |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Company of Biologists Ltd
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5087660/ https://ncbi.nlm.nih.gov/pubmed/27591258 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.191585 |
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