Mutant IP(3) receptors attenuate store-operated Ca(2+) entry by destabilizing STIM–Orai interactions in Drosophila neurons

Store-operated Ca(2+) entry (SOCE) occurs when loss of Ca(2+) from the endoplasmic reticulum (ER) stimulates the Ca(2+) sensor, STIM, to cluster and activate the plasma membrane Ca(2+) channel Orai (encoded by Olf186-F in flies). Inositol 1,4,5-trisphosphate receptors (IP(3)Rs, which are encoded by...

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Vydáno v:J Cell Sci
Hlavní autoři: Chakraborty, Sumita, Deb, Bipan K., Chorna, Tetyana, Konieczny, Vera, Taylor, Colin W., Hasan, Gaiti
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists Ltd 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087660/
https://ncbi.nlm.nih.gov/pubmed/27591258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.191585
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