Transient ectopic expression of the histone demethylase JMJD3 accelerates the differentiation of human pluripotent stem cells

Harnessing epigenetic regulation is crucial for the efficient and proper differentiation of pluripotent stem cells (PSCs) into desired cell types. Histone H3 lysine 27 trimethylation (H3K27me3) functions as a barrier against cell differentiation through the suppression of developmental gene expressi...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Development
Main Authors: Akiyama, Tomohiko, Wakabayashi, Shunichi, Soma, Atsumi, Sato, Saeko, Nakatake, Yuhki, Oda, Mayumi, Murakami, Miyako, Sakota, Miki, Chikazawa-Nohtomi, Nana, Ko, Shigeru B. H., Ko, Minoru S. H.
Format: Artigo
Jezik:Inglês
Izdano: The Company of Biologists Ltd 2016
Teme:
Stem Cells and Regeneration
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087640/
https://ncbi.nlm.nih.gov/pubmed/27802135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.139360
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