Therapeutic CD94/NKG2A blockade improves natural killer cell dysfunction in chronic lymphocytic leukemia

Natural killer (NK)-cell count is predictive of chronic lymphoid leukemia (CLL) disease progression and their dysfunction is well documented, but the etiology of this is currently lacking. CLL cells have been shown to over-express HLA-E, the natural ligand for NKG2A expressed on NK-cells that genera...

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Vydáno v:Oncoimmunology
Hlavní autoři: McWilliams, Emily M., Mele, Jennifer M., Cheney, Carolyn, Timmerman, Elizabeth A., Fiazuddin, Faraz, Strattan, Ethan J., Mo, Xiaokui, Byrd, John C., Muthusamy, Natarajan, Awan, Farrukh T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2016
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087289/
https://ncbi.nlm.nih.gov/pubmed/27853650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1226720
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