Therapeutic CD94/NKG2A blockade improves natural killer cell dysfunction in chronic lymphocytic leukemia

Natural killer (NK)-cell count is predictive of chronic lymphoid leukemia (CLL) disease progression and their dysfunction is well documented, but the etiology of this is currently lacking. CLL cells have been shown to over-express HLA-E, the natural ligand for NKG2A expressed on NK-cells that genera...

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Bibliografiske detaljer
Udgivet i:Oncoimmunology
Main Authors: McWilliams, Emily M., Mele, Jennifer M., Cheney, Carolyn, Timmerman, Elizabeth A., Fiazuddin, Faraz, Strattan, Ethan J., Mo, Xiaokui, Byrd, John C., Muthusamy, Natarajan, Awan, Farrukh T.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2016
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087289/
https://ncbi.nlm.nih.gov/pubmed/27853650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1226720
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