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Mechanism of O(2) activation and substrate hydroxylation in noncoupled binuclear copper monooxygenases
Peptidylglycine α-hydroxylating monooxygenase (PHM) and dopamine β-monooxygenase (DβM) are copper-dependent enzymes that are vital for neurotransmitter regulation and hormone biosynthesis. These enzymes feature a unique active site consisting of two spatially separated (by 11 Å in PHM) and magnetica...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5087064/ https://ncbi.nlm.nih.gov/pubmed/27790986 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614807113 |
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