Tilting the balance between RNA interference and replication eradicates Leishmania RNA virus 1 and mitigates the inflammatory response

Many Leishmania (Viannia) parasites harbor the double-stranded RNA virus Leishmania RNA virus 1 (LRV1), which has been associated with increased disease severity in animal models and humans and with drug treatment failures in humans. Remarkably, LRV1 survives in the presence of an active RNAi pathwa...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Brettmann, Erin A., Shaik, Jahangheer S., Zangger, Haroun, Lye, Lon-Fye, Kuhlmann, F. Matthew, Akopyants, Natalia S., Oschwald, Dayna M., Owens, Katherine L., Hickerson, Suzanne M., Ronet, Catherine, Fasel, Nicolas, Beverley, Stephen M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5087061/
https://ncbi.nlm.nih.gov/pubmed/27790981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1615085113
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