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Extracellular matrix stiffness causes systematic variations in proliferation and chemosensitivity in myeloid leukemias

Extracellular matrix stiffness influences biological functions of some tumors. However, it remains unclear how cancer subtypes with different oncogenic mutations respond to matrix stiffness. In addition, the relevance of matrix stiffness to in vivo tumor growth kinetics and drug efficacy remains elu...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Shin, Jae-Won, Mooney, David J.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5086998/
https://ncbi.nlm.nih.gov/pubmed/27790998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1611338113
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