Proteolytic processing of Middle East respiratory syndrome coronavirus spikes expands virus tropism

Middle East respiratory syndrome coronavirus (MERS-CoV) infects humans from zoonotic sources and causes severe pulmonary disease. Virions require spike (S) glycoproteins for binding to cell receptors and for catalyzing virus–cell membrane fusion. Fusion occurs only after S proteins are cleaved seque...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Park, Jung-Eun, Li, Kun, Barlan, Arlene, Fehr, Anthony R., Perlman, Stanley, McCray, Paul B., Gallagher, Tom
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5086990/
https://ncbi.nlm.nih.gov/pubmed/27791014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1608147113
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