Targeted disruption of the murine Na+/H+ exchanger isoform 2 gene causes reduced viability of gastric parietal cells and loss of net acid secretion.

Multiple isoforms of the Na+/H+ exchanger (NHE) are expressed at high levels in gastric epithelium, but the physiological role of individual isoforms is unclear. To study the function of NHE2, which is expressed in mucous, zymogenic, and parietal cells, we prepared mice with a null mutation in the N...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Schultheis, P J, Clarke, L L, Meneton, P, Harline, M, Boivin, G P, Stemmermann, G, Duffy, J J, Doetschman, T, Miller, M L, Shull, G E
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508678/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9502765/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI1249
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