Increased sphingomyelin content of plasma lipoproteins in apolipoprotein E knockout mice reflects combined production and catabolic defects and enhances reactivity with mammalian sphingomyelinase.

Apolipoprotein E knockout (apoE0) mice accumulate atherogenic remnant lipoproteins in plasma. We now provide evidence that these particles are enriched in sphingomyelin (SM), and explore the mechanisms and possible pathophysiological consequences of this finding. The phosphatidylcholine/sphingomyeli...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Main Authors: Jeong, Ts, Schissel, S L, Tabas, I, Pownall, H J, Tall, A R, Jiang, X
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 1998
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508639/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9466986/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI870
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