Activated human protein C prevents thrombin-induced thromboembolism in mice. Evidence that activated protein c reduces intravascular fibrin accumulation through the inhibition of additional thrombin generation.

Activated protein C (APC) is a potent physiologic anticoagulant with profibrinolytic properties, and has been shown to prevent thrombosis in different experimental models. We investigated the effect of human APC on thrombin-induced thromboembolism in mice, a model of acute intravascular fibrin depos...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Gresele, P, Momi, S, Berrettini, M, Nenci, G G, Schwarz, H P, Semeraro, N, Colucci, M
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1998
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508611/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9449701/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI575
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