Lens-specific expression of transforming growth factor beta1 in transgenic mice causes anterior subcapsular cataracts.

Transgenic mice were generated by microinjection of a construct containing a self-activating human TGF-beta1 cDNA driven by the lens-specific alphaA-crystallin promoter. Seven transgenic founder mice were generated, and four transgenic lines expressing TGF-beta1 were characterized. By postnatal day...

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Main Authors: Srinivasan, Y, Lovicu, F J, Overbeek, P A
Format: Artigo
Sprog:Inglês
Udgivet: 1998
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC508606/
https://ncbi.nlm.nih.gov/pubmed/9449696
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