Metabolic Response to XD14 Treatment in Human Breast Cancer Cell Line MCF-7

XD14 is a 4-acyl pyrrole derivative, which was discovered by a high-throughput virtual screening experiment. XD14 inhibits bromodomain and extra-terminal domain (BET) proteins (BRD2, BRD3, BRD4 and BRDT) and consequently suppresses cell proliferation. In this study, metabolic profiling reveals the m...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Pan, Daqiang, Kather, Michel, Willmann, Lucas, Schlimpert, Manuel, Bauer, Christoph, Lagies, Simon, Schmidtkunz, Karin, Eisenhardt, Steffen U., Jung, Manfred, Günther, Stefan, Kammerer, Bernd
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085796/
https://ncbi.nlm.nih.gov/pubmed/27783056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17101772
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