Muscle oxidative phosphorylation quantitation using creatine chemical exchange saturation transfer (CrCEST) MRI in mitochondrial disorders

Systemic mitochondrial energy deficiency is implicated in the pathophysiology of many age-related human diseases. Currently available tools to estimate mitochondrial oxidative phosphorylation (OXPHOS) capacity in skeletal muscle in vivo lack high anatomic resolution. Muscle groups vary with respect...

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Publicat a:JCI Insight
Autors principals: DeBrosse, Catherine, Nanga, Ravi Prakash Reddy, Wilson, Neil, D’Aquilla, Kevin, Elliott, Mark, Hariharan, Hari, Yan, Felicia, Wade, Kristin, Nguyen, Sara, Worsley, Diana, Parris-Skeete, Chevonne, McCormick, Elizabeth, Xiao, Rui, Cunningham, Zuela Zolkipli, Fishbein, Lauren, Nathanson, Katherine L., Lynch, David R., Stallings, Virginia A., Yudkoff, Marc, Falk, Marni J., Reddy, Ravinder, McCormack, Shana E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2016
Matèries:
Technical Advance
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085612/
https://ncbi.nlm.nih.gov/pubmed/27812541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.88207
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