Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse.

Intracellular insulin signaling involves a series of alternative and complementary pathways created by the multiple substrates of the insulin receptor (IRS) and the various isoforms of SH2 domain signaling molecules that can interact with these substrates. In this study, we have evaluated the roles...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Kerouz, N J, Hörsch, D, Pons, S, Kahn, C R
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 1997
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508530/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9399964/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119872
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