SOX2 functions as a molecular rheostat to control the growth, tumorigenicity and drug responses of pancreatic ductal adenocarcinoma cells

Pancreatic ductal adenocarcinoma (PDAC) is a highly deadly malignancy. Expression of the stem cell transcription factor SOX2 increases during progression of PDAC. Knockdown of SOX2 in PDAC cell lines decreases growth in vitro; whereas, stable overexpression of SOX2 in one PDAC cell line reportedly i...

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Bibliografische gegevens
Gepubliceerd in:Oncotarget
Hoofdauteurs: Wuebben, Erin L., Wilder, Phillip J., Cox, Jesse L., Grunkemeyer, James A., Caffrey, Thomas, Hollingsworth, Michael A., Rizzino, Angie
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2016
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Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085197/
https://ncbi.nlm.nih.gov/pubmed/27145457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8994
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