MECP2 promotes the growth of gastric cancer cells by suppressing miR-338-mediated antiproliferative effect

The methyl-CpG-binding protein 2 (MECP2), a transcriptional suppressor, is involved in gene regulation by binding to methylated promoters. We found that MECP2 is overexpressed in gastric cancer (GC), and that Mecp2 knockdown affects the growth of GC cells both in vitro and in vivo. MECP2 can directl...

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Vydáno v:Oncotarget
Hlavní autoři: Tong, Dongdong, Zhao, Lingyu, He, Kang, Sun, Hongfei, Cai, Donghui, Ni, Lei, Sun, Ruifang, Chang, Su'e, Song, Tusheng, Huang, Chen
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085194/
https://ncbi.nlm.nih.gov/pubmed/27166996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9197
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