A functional variant at miRNA-122 binding site in IL-1α 3′ UTR predicts risk of recurrence in patients with oropharyngeal cancer

IL-1α, an important regulator of immune and inflammation responses, has been implicated in cancer development and prognosis. An insertion (Ins)/deletion (Del) polymorphism (IL-1α rs3783553) in the 3′ UTR of IL-1α may disrupt a binding site for miRNA-122 and may affect its transcription level. Thus,...

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Vydáno v:Oncotarget
Hlavní autoři: Wang, Chengyuan, Sturgis, Erich M., Chen, Xingming, Wei, Qingyi, Li, Guojun
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085169/
https://ncbi.nlm.nih.gov/pubmed/27121322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8908
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