Targeting hypoxic microenvironment of pancreatic xenografts with the hypoxia-activated prodrug TH-302

Previous reports have suggested that the hypoxic microenvironment provides a niche that supports tumor stem cells, and that this might explain clinical observations linking hypoxia to metastasis. To test this, we examined the effects of a hypoxia-activated prodrug, TH-302, on the tumor-initiating ce...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Lohse, Ines, Rasowski, Joanna, Cao, Pinjiang, Pintilie, Melania, Do, Trevor, Tsao, Ming-Sound, Hill, Richard P., Hedley, David W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
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Priority Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085103/
https://ncbi.nlm.nih.gov/pubmed/27248663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9654
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