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Targeting hypoxic microenvironment of pancreatic xenografts with the hypoxia-activated prodrug TH-302
Previous reports have suggested that the hypoxic microenvironment provides a niche that supports tumor stem cells, and that this might explain clinical observations linking hypoxia to metastasis. To test this, we examined the effects of a hypoxia-activated prodrug, TH-302, on the tumor-initiating ce...
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| Vydáno v: | Oncotarget |
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| Hlavní autoři: | , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Impact Journals LLC
2016
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5085103/ https://ncbi.nlm.nih.gov/pubmed/27248663 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9654 |
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