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Hydrogen Bond Dynamic Propensity Studies for Protein Binding and Drug Design
We study the dynamic propensity of the backbone hydrogen bonds of the protein MDM2 (the natural regulator of the tumor suppressor p53) in order to determine its binding properties. This approach is fostered by the observation that certain backbone hydrogen bonds at the p53-binding site exhibit a dyn...
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| Pubblicato in: | PLoS One |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5085089/ https://ncbi.nlm.nih.gov/pubmed/27792778 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0165767 |
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