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Combinatorial immunotherapeutic approaches to restore the function of anergic tumor-reactive cytotoxic CD8(+) T cells

Numerous preclinical studies have demonstrated that combination immunotherapy can significantly reduce tumor growth and improve overall survival as compared to monotherapy. Furthermore, dual CTLA-4/PD-1 checkpoint blockade recently received FDA-approval for patients with metastatic melanoma, becomin...

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Detalhes bibliográficos
Publicado no:Hum Vaccin Immunother
Main Authors: Redmond, William L., Linch, Stefanie N.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5084978/
https://ncbi.nlm.nih.gov/pubmed/27459422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21645515.2016.1193277
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