Tumor necrosis factor-alpha contributes to obesity-related hyperleptinemia by regulating leptin release from adipocytes.

Cytokines, in particular tumor necrosis factor-alpha (TNF-alpha), have significant effects on energy metabolism and appetite although their mechanisms of action are largely unknown. Here, we examined whether TNF-alpha modulates the production of leptin, the recently identified fat-specific energy ba...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Kirchgessner, T G, Uysal, K T, Wiesbrock, S M, Marino, M W, Hotamisligil, G S
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508482/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9389742/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119824
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