Initiating sacubitril/valsartan (LCZ696) in heart failure: results of TITRATION, a double‐blind, randomized comparison of two uptitration regimens

AIMS: To assess the tolerability of initiating/uptitrating sacubitril/valsartan (LCZ696) from 50 to 200 mg twice daily (target dose) over 3 and 6 weeks in heart failure (HF) patients (ejection fraction ≤35%). METHODS AND RESULTS: A 5‐day open‐label run‐in (sacubitril/valsartan 50 mg twice daily) pre...

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Detalhes bibliográficos
Publicado no:Eur J Heart Fail
Main Authors: Senni, Michele, McMurray, John J.V., Wachter, Rolf, McIntyre, Hugh F., Reyes, Antonio, Majercak, Ivan, Andreka, Peter, Shehova‐Yankova, Nina, Anand, Inder, Yilmaz, Mehmet B., Gogia, Harinder, Martinez‐Selles, Manuel, Fischer, Steffen, Zilahi, Zsolt, Cosmi, Franco, Gelev, Valeri, Galve, Enrique, Gómez‐Doblas, Juanjo J., Nociar, Jan, Radomska, Maria, Sokolova, Beata, Volterrani, Maurizio, Sarkar, Arnab, Reimund, Bernard, Chen, Fabian, Charney, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2016
Assuntos:
Medical Treatment
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5084812/
https://ncbi.nlm.nih.gov/pubmed/27170530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ejhf.548
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