Activation of the prolactin receptor but not the growth hormone receptor is important for induction of mammary tumors in transgenic mice.

Transgenic mice overexpressing the human growth hormone gene develop mammary carcinomas. Since human growth hormone gene can activate both the growth hormone receptor (GHR) and the prolactin (PRL) receptor (PRLR), it is not clear which receptor system is responsible for the malignant transformation....

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Main Authors: Wennbo, H, Gebre-Medhin, M, Gritli-Linde, A, Ohlsson, C, Isaksson, O G, Törnell, J
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC508478/
https://ncbi.nlm.nih.gov/pubmed/9389738
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