Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice.

Obesity is associated with diabetes, and leptin is known to be elevated in obesity. To investigate whether leptin has a direct effect on insulin secretion, isolated rat and human islets and cultured insulinoma cells were studied. In all cases, mouse leptin inhibited insulin secretion at concentratio...

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Detalhes bibliográficos
Main Authors: Kulkarni, R N, Wang, Z L, Wang, R M, Hurley, J D, Smith, D M, Ghatei, M A, Withers, D J, Gardiner, J V, Bailey, C J, Bloom, S R
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC508476/
https://ncbi.nlm.nih.gov/pubmed/9389736
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