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Exclusive transmission of the embryonic stem cell‐derived genome through the mouse germline

Gene targeting in embryonic stem (ES) cells remains best practice for introducing complex mutations into the mouse germline. One aspect in this multistep process that has not been streamlined with regard to the logistics and ethics of mouse breeding is the efficiency of germline transmission: the tr...

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Detalhes bibliográficos
Publicado no:Genesis
Main Authors: Koentgen, Frank, Lin, Jiangwei, Katidou, Markella, Chang, Isabelle, Khan, Mona, Watts, Jacqui, Mombaerts, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5084746/
https://ncbi.nlm.nih.gov/pubmed/27012318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvg.22938
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