Direct in vivo inhibition of the nuclear cell cycle cascade in experimental mesangial proliferative glomerulonephritis with Roscovitine, a novel cyclin-dependent kinase antagonist.

Glomerular injury is characterized by mesangial cell (MC) proliferation and matrix formation. We sought to determine if reducing the activity of cyclin-dependent kinase 2 (CDK2) with the purine analogue, Roscovitine, decreased MC proliferation in vitro and in vivo. Roscovitine (25 microM) inhibited...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Pippin, J W, Qu, Q, Meijer, L, Shankland, S J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508451/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9366565/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119793
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