Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833.

Lignende værker

• Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833.
  af: van Asperen, J., et al.
  Udgivet: (1997)
• Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein.
  af: Mayer, U., et al.
  Udgivet: (1996)
• Cytotoxic effect of the cyclosporin PSC 833 in multidrug-resistant leukaemia cells with increased expression of P-glycoprotein.
  af: Lehne, G., et al.
  Udgivet: (1998)
• Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine
  af: Sparreboom, Alex, et al.
  Udgivet: (1997)
• P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.
  af: Schinkel, A H, et al.
  Udgivet: (1996)