Cardiac compartment-specific overexpression of a modified retinoic acid receptor produces dilated cardiomyopathy and congestive heart failure in transgenic mice.

Retinoids play a critical role in cardiac morphogenesis. To examine the effects of excessive retinoid signaling on myocardial development, transgenic mice that overexpress a constitutively active retinoic acid receptor (RAR) controlled by either the alpha- or beta-myosin heavy chain (MyHC) promoter...

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Autors principals: Colbert, M C, Hall, D G, Kimball, T R, Witt, S A, Lorenz, J N, Kirby, M L, Hewett, T E, Klevitsky, R, Robbins, J
Format: Artigo
Idioma:Inglês
Publicat: 1997
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC508385/
https://ncbi.nlm.nih.gov/pubmed/9329959
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