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Drug interactions may be important risk factors for methotrexate neurotoxicity, particularly in pediatric leukemia patients
PURPOSE: Methotrexate administration is associated with frequent adverse neurological events during treatment for childhood acute lymphoblastic leukemia. Here, we present evidence to support the role of common drug interactions and low vitamin B(12) levels in potentiating methotrexate neurotoxicity....
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| Publicado no: | Cancer Chemother Pharmacol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Berlin Heidelberg
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5083755/ https://ncbi.nlm.nih.gov/pubmed/27659182 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-016-3153-0 |
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