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Dabigatran antagonizes growth, cell‐cycle progression, migration, and endothelial tube formation induced by thrombin in breast and glioblastoma cell lines

Thrombin activates its G‐coupled seven transmembrane protease‐activated receptor (PAR‐1) by cleaving the receptor's N‐terminal end. In several human cancers, PAR1 expression and activation correlates with tumor progression and metastatization. This provides compelling evidence for the effective...

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Detalhes bibliográficos
Publicado no:Cancer Med
Main Authors: Vianello, Fabrizio, Sambado, Luisa, Goss, Ashley, Fabris, Fabrizio, Prandoni, Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5083743/
https://ncbi.nlm.nih.gov/pubmed/27600331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.857
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