Long interspersed nuclear element-1 retroelements are expressed in patients with systemic autoimmune disease and induce type I interferon

OBJECTIVE: Increased type I interferon (IFN-I) and a broad signature of IFN-I-induced gene transcripts are observed in patients with SLE and other systemic autoimmune diseases. To identify disease-relevant triggers of the IFN-I pathway we investigated whether endogenous virus-like genomic repeat ele...

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Vydáno v:Arthritis Rheumatol
Hlavní autoři: Mavragani, Clio P., Sagalovskiy, Irina, Guo, Qiu, Nezos, Adrianos, Kapsogeorgou, Efstathia K., Lu, Pin, Zhou, Jun Liang, Kirou, Kyriakos A., Seshan, Surya V., Moutsopoulos, Haralampos M., Crow, Mary K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5083133/
https://ncbi.nlm.nih.gov/pubmed/27338297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39795
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