Gi-DREADD Expression in Peripheral Nerves Produces Ligand-Dependent Analgesia, as well as Ligand-Independent Functional Changes in Sensory Neurons

Designer receptors exclusively activated by designer drugs (DREADDs) are an advanced experimental tool that could potentially provide a novel approach to pain management. In particular, expression of an inhibitory (Gi-coupled) DREADD in nociceptors might enable ligand-dependent analgesia. To test th...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Saloman, Jami L., Scheff, Nicole N., Snyder, Lindsey M., Ross, Sarah E., Davis, Brian M., Gold, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5083007/
https://ncbi.nlm.nih.gov/pubmed/27798132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3480-15.2016
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