Leptin constrains acetylcholine-induced insulin secretion from pancreatic islets of ob/ob mice.
Hypersecretion of insulin from the pancreas is among the earliest detectable metabolic alterations in some genetically obese animals including the ob/ob mouse and in some obesity-prone humans. Since the primary cause of obesity in the ob/ob mouse is a lack of leptin due to a mutation in the ob gene,...
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| Publicado no: | J Clin Invest |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508293/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9276734/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119629 |
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