Assessment of the Effects of MPTP and Paraquat on Dopaminergic Neurons and Microglia in the Substantia Nigra Pars Compacta of C57BL/6 Mice

The neurotoxicity of paraquat dichloride (PQ) was assessed in two inbred strains of 9- or 16-week old male C57BL/6 mice housed in two different laboratories and compared to the effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). PQ was administered by intraperitoneal injections; either o...

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Udgivet i:PLoS One
Main Authors: Smeyne, Richard Jay, Breckenridge, Charles B., Beck, Melissa, Jiao, Yun, Butt, Mark T., Wolf, Jeffrey C., Zadory, Dan, Minnema, Daniel J., Sturgess, Nicholas C., Travis, Kim Z., Cook, Andrew R., Smith, Lewis L., Botham, Philip A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5082881/
https://ncbi.nlm.nih.gov/pubmed/27788145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164094
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