Recognition of the immunodominant myelin basic protein peptide by autoantibodies and HLA-DR2-restricted T cell clones from multiple sclerosis patients. Identity of key contact residues in the B-cell and T-cell epitopes.

Myelin basic protein (MBP) may be an important autoantigen in multiple sclerosis (MS), with the MBP(82-100) region being immunodominant for T cells and autoantibodies. The structural requirements for autoantibody recognition were compared to those previously defined for MBP-specific T cell clones. M...

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Detalles Bibliográficos

Publicado en:	J Clin Invest
Principais autores:	Wucherpfennig, K W, Catz, I, Hausmann, S, Strominger, J L, Steinman, L, Warren, K G
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Clinical Investigation 1997
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508286/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9276728/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119622
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