A novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune disease.

A novel polymorphism in the extracellular domain 2 (EC2) of FcgammaRIIIA affects ligand binding by natural killer (NK) cells and monocytes from genotyped homozygous normal donors independently of receptor expression. The nonconservative T to G substitution at nucleotide 559 predicts a change of phen...

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Publicado no:	J Clin Invest
Principais autores:	Wu, J, Edberg, J C, Redecha, P B, Bansal, V, Guyre, P M, Coleman, K, Salmon, J E, Kimberly, R P
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1997
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508280/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9276722/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119616
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