Altered T cell phenotypes associated with clinical relapse of multiple sclerosis patients receiving fingolimod therapy

Multiple sclerosis (MS) is a T cell-mediated autoimmune disease. Fingolimod, a highly effective disease-modifying drug for MS, retains CCR7(+) central memory T cells in which autoaggressive T cells putatively exist, in secondary lymphoid organs, although relapse may still occur in some patients. Her...

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Publicat a:Sci Rep
Autors principals: Fujii, Chihiro, Kondo, Takayuki, Ochi, Hirofumi, Okada, Yoichiro, Hashi, Yuichiro, Adachi, Tetsuya, Shin-Ya, Masaharu, Matsumoto, Sadayuki, Takahashi, Ryosuke, Nakagawa, Masanori, Mizuno, Toshiki
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5082790/
https://ncbi.nlm.nih.gov/pubmed/27752051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35314
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