Inhibition of autophagosome-lysosome fusion by ginsenoside Ro via the ESR2-NCF1-ROS pathway sensitizes esophageal cancer cells to 5-fluorouracil-induced cell death via the CHEK1-mediated DNA damage checkpoint

Modulation of autophagy has been increasingly regarded as a promising cancer therapeutic approach. In this study, we screened several ginsenosides extracted from Panax ginseng and identified ginsenoside Ro (Ro) as a novel autophagy inhibitor. Ro blocked the autophagosome-lysosome fusion process by r...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Zheng, Kai, Li, Yan, Wang, Shaoxiang, Wang, Xiao, Liao, Chenghui, Hu, Xiaopeng, Fan, Long, Kang, Qiangrong, Zeng, Yong, Wu, Xuli, Wu, Haiqiang, Zhang, Jian, Wang, Yifei, He, Zhendan
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Basic Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5082787/
https://ncbi.nlm.nih.gov/pubmed/27310928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1192751
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