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Autophagy activation by novel inducers prevents BECN2-mediated drug tolerance to cannabinoids

Cannabinoids and related drugs generate profound behavioral effects (such as analgesic effects) through activating CNR1 (cannabinoid receptor 1 [brain]). However, repeated cannabinoid administration triggers lysosomal degradation of the receptor and rapid development of drug tolerance, limiting the...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Kuramoto, Kenta, Wang, Nan, Fan, Yuying, Zhang, Weiran, Schoenen, Frank J., Frankowski, Kevin J., Marugan, Juan, Zhou, Yifa, Huang, Sui, He, Congcong
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5082783/
https://ncbi.nlm.nih.gov/pubmed/27305347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1187367
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