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Autophagy activation by novel inducers prevents BECN2-mediated drug tolerance to cannabinoids
Cannabinoids and related drugs generate profound behavioral effects (such as analgesic effects) through activating CNR1 (cannabinoid receptor 1 [brain]). However, repeated cannabinoid administration triggers lysosomal degradation of the receptor and rapid development of drug tolerance, limiting the...
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Publicado no: | Autophagy |
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Main Authors: | , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Taylor & Francis
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5082783/ https://ncbi.nlm.nih.gov/pubmed/27305347 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1187367 |
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