Hypoxanthine induces cholesterol accumulation and incites atherosclerosis in apolipoprotein E‐deficient mice and cells

Reactive oxygen species (ROS) generation during purine metabolism is associated with xanthine oxidase and uric acid. However, the direct effect of hypoxanthine on ROS generation and atherosclerosis has not been evaluated. Smoking and heavy drinking are associated with elevated levels of hypoxanthine...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Ryu, Hye‐Myung, Kim, You‐Jin, Oh, Eun‐Joo, Oh, Se‐Hyun, Choi, Ji‐Young, Cho, Jang‐Hee, Kim, Chan‐Duck, Park, Sun‐Hee, Kim, Yong‐Lim
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5082407/
https://ncbi.nlm.nih.gov/pubmed/27396856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12916
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