Neuroprotective Effect of the Marine-Derived Compound 11-Dehydrosinulariolide through DJ-1-Related Pathway in In Vitro and In Vivo Models of Parkinson’s Disease

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by tremor, rigidity, bradykinesia, and gait impairment. In a previous study, we found that the marine-derived compound 11-dehydrosinulariolide (11-de) upregulates the Akt/PI3K pathway to protect cells against 6-hydroxydopamine (6...

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Udgivet i:Mar Drugs
Main Authors: Feng, Chien-Wei, Hung, Han-Chun, Huang, Shi-Ying, Chen, Chun-Hong, Chen, Yun-Ru, Chen, Chun-Yu, Yang, San-Nan, Wang, Hui-Min David, Sung, Ping-Jyun, Sheu, Jyh-Horng, Tsui, Kuan-Hao, Chen, Wu-Fu, Wen, Zhi-Hong
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5082335/
https://ncbi.nlm.nih.gov/pubmed/27763504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md14100187
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