Novel Spray Dried Glycerol 2-Phosphate Cross-Linked Chitosan Microparticulate Vaginal Delivery System—Development, Characterization and Cytotoxicity Studies

Chitosan microparticulate delivery systems containing clotrimazole were prepared by a spray drying technique using glycerol 2-phosphate as an ion cross-linker. The impact of a cross-linking ratio on microparticle characteristics was evaluated. Drug-free and drug-loaded unmodified or ion cross-linked...

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Bibliographic Details
Published in:Mar Drugs
Main Authors: Szymańska, Emilia, Szekalska, Marta, Czarnomysy, Robert, Lavrič, Zoran, Srčič, Stane, Miltyk, Wojciech, Winnicka, Katarzyna
Format: Artigo
Language:Inglês
Published: MDPI 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5082322/
https://ncbi.nlm.nih.gov/pubmed/27690062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md14100174
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