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Immunodominance of a low-affinity major histocompatibility complex-binding myelin basic protein epitope (residues 111-129) in HLA-DR4 (B1*0401) subjects is associated with a restricted T cell receptor repertoire.

The pathogenesis of multiple sclerosis (MS) is currently ascribed in part to a T cell-mediated process targeting myelin components. The T cell response to one candidate autoantigen, myelin basic protein (MBP), in the context of HLA-DR15Dw2, has been previously studied in detail. However, the charact...

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Udgivet i:J Clin Invest
Principais autores: Muraro, P A, Vergelli, M, Kalbus, M, Banks, D E, Nagle, J W, Tranquill, L R, Nepom, G T, Biddison, W E, McFarland, H F, Martin, R
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508196/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9218510/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119539
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