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Inhibitors of the proteasome reduce the accelerated proteolysis in atrophying rat skeletal muscles.

Several observations have suggested that the enhanced proteolysis and atrophy of skeletal muscle in various pathological states is due primarily to activation of the ubiquitin-proteasome pathway. To test this idea, we investigated whether peptide aldehyde inhibitors of the proteasome, N-acetyl-leucy...

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Bibliografske podrobnosti
Main Authors: Tawa, N E, Odessey, R, Goldberg, A L
Format: Artigo
Jezik:Inglês
Izdano: 1997
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC508180/
https://ncbi.nlm.nih.gov/pubmed/9202072
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