Mutational landscape of EGFR-, MYC-, and Kras-driven genetically engineered mouse models of lung adenocarcinoma

Genetically engineered mouse models (GEMMs) of cancer are increasingly being used to assess putative driver mutations identified by large-scale sequencing of human cancer genomes. To accurately interpret experiments that introduce additional mutations, an understanding of the somatic genetic profile...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: McFadden, David G., Politi, Katerina, Bhutkar, Arjun, Chen, Frances K., Song, Xiaoling, Pirun, Mono, Santiago, Philip M., Kim-Kiselak, Caroline, Platt, James T., Lee, Emily, Hodges, Emily, Rosebrock, Adam P., Bronson, Roderick T., Socci, Nicholas D., Hannon, Gregory J., Jacks, Tyler, Varmus, Harold
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081629/
https://ncbi.nlm.nih.gov/pubmed/27702896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613601113
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