Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity

Synucleinopathies are a group of progressive disorders characterized by the abnormal aggregation and accumulation of α-synuclein (aSyn), an abundant neuronal protein that can adopt different conformations and biological properties. Recently, aSyn pathology was shown to spread between neurons in a pr...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Villar-Piqué, Anna, Lopes da Fonseca, Tomás, Sant’Anna, Ricardo, Szegö, Éva Mónika, Fonseca-Ornelas, Luis, Pinho, Raquel, Carija, Anita, Gerhardt, Ellen, Masaracchia, Caterina, Abad Gonzalez, Enrique, Rossetti, Giulia, Carloni, Paolo, Fernández, Claudio O., Foguel, Debora, Milosevic, Ira, Zweckstetter, Markus, Ventura, Salvador, Outeiro, Tiago Fleming
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2016
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PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081623/
https://ncbi.nlm.nih.gov/pubmed/27708160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1606791113
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