Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs

Chromatin structure orchestrates the accessibility to the genetic material. Replication-independent histone variants control transcriptional plasticity in postmitotic cells. The life-long accumulation of these histones has been described, yet the implications on organismal aging remain elusive. Here...

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Gepubliceerd in:Cell Rep
Hoofdauteurs: Piazzesi, Antonia, Papić, Dražen, Bertan, Fabio, Salomoni, Paolo, Nicotera, Pierluigi, Bano, Daniele
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cell Press 2016
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Report
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081402/
https://ncbi.nlm.nih.gov/pubmed/27760329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.09.074
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