Anti-beta2-glycoprotein I (beta2GPI) monoclonal antibodies with lupus anticoagulant-like activity enhance the beta2GPI binding to phospholipids.

beta2-Glycoprotein I (beta2GPI), a plasma glycoprotein with phospholipid-binding property, is known to be the actual target antigen for autoimmune type anticardiolipin antibodies (aCLs). Certain groups of aCLs (anti-beta2GPI antibodies) exert lupus anticoagulant (LA) activity and perturb the functio...

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Publicado en:J Clin Invest
Main Authors: Takeya, H., Mori, T., Gabazza, E. C., Kuroda, K., Deguchi, H., Matsuura, E., Ichikawa, K., Koike, T., Suzuki, K.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 1997
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508058/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9151800/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119401
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