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Rapamycin (sirolimus) inhibits proliferating cell nuclear antigen expression and blocks cell cycle in the G1 phase in human keratinocyte stem cells.

Because the immunosuppressant rapamycin (sirolimus) blocks T cell proliferation in G1 phase, it has been proposed as a potential treatment for psoriasis, a skin disease characterized by T cell activation and keratinocyte stem cell hyperproliferation. To determine another potentially important mechan...

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Библиографические подробности
Главные авторы: Javier, A. F., Bata-Csorgo, Z., Ellis, C. N., Kang, S., Voorhees, J. J., Cooper, K. D.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 1997
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC508039/
https://ncbi.nlm.nih.gov/pubmed/9151781
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