Molecular mechanisms and selective influences that shape the kappa gene repertoire of IgM+ B cells.

To analyze the human kappa chain repertoire and the influences that shape it, a single cell PCR technique was used that amplified Vkappa Jkappa rearrangements from genomic DNA of individual human B cells. More than 350 productive and 250 nonproductive Vkappa Jkappa rearrangements were sequenced. Nea...

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Pubblicato in:	J Clin Invest
Autori principali:	Foster, S J, Brezinschek, H P, Brezinschek, R I, Lipsky, P E
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1997
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507981/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9120005/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119324
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